Table 4. Increase in serum lipid levels with an increase of alcohol intake by 10 g/day according to the combinations of ADH1B and ALDH2 genotypes in the main studya.
| Loge-triglycerides (mg/dL) | Loge-HDL cholesterol (mg/dL) | LDL cholesterol (mg/dL) | |||||||
| n | β | (95% Cl) | n | β | (95% Cl) | n | β | (95% Cl) | |
| Combinations of genotypes | |||||||||
| ADH1B His/His + ALDH2 Glu/Glu | 275 | 0.010 | (−0.010 to 0.030) | 275 | 0.023 | (0.013–0.032) | 270 | −0.52 | (−1.85 to 0.80) |
| P for interaction | reference | reference | reference | ||||||
| ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys | 242 | 0.032 | (0.0007–0.064) | 242 | 0.020 | (0.005–0.036) | 238 | −3.24 | (−5.03 to −1.45) |
| P for interaction | 0.473 | 0.713 | 0.010 | ||||||
| ADH1B His/Arg or Arg/Arg + ALDH2 Glu/Glu | 207 | −0.011 | (−0.038 to 0.017) | 207 | 0.028 | (0.016–0.040) | 200 | −0.97 | (−2.50 to 0.55) |
| P for interaction | 0.161 | 0.537 | 0.548 | ||||||
| ADH1B His/Arg or Arg/Arg + ALDH2 Glu/Lys or Lys/Lys | 165 | −0.031 | (−0.066 to 0.004) | 165 | 0.020 | (0.002–0.038) | 164 | −0.90 | (−3.09 to 1.30) |
| P for interaction | 0.017 | 0.890 | 0.109 | ||||||
CI, confidence interval; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
aDetermined by linear regression analysis adjusted for age, physical activity, body mass index, energy intake, study area, education, diabetes and smoking status as covariates.