Table 5. Increase in serum lipid levels with an increase of alcohol intake by 10 g/day according to the genotypes of ALDH2 in the replication studya.
| Loge-triglycerides (mg/dL) | Loge-HDL cholesterol (mg/dL) | LDL cholesterol (mg/dL) | |||||||
| n | β | (95% Cl) | n | β | (95% Cl) | n | β | (95% Cl) | |
| All | 2562 | 0.008 | (0.001–0.016) | 2562 | 0.020 | (0.016–0.024) | 2531 | −1.23 | (−1.70 to −0.77) |
| Genotypes | |||||||||
| ALDH2 (rs671) | |||||||||
| Glu/Glu | 1253 | 0.009 | (−0.001 to 0.018) | 1253 | 0.013 | (0.008–0.018) | 1237 | −0.79 | (−1.38 to −0.19) |
| P for interaction | reference | reference | reference | ||||||
| Glu/Lys or Lys/Lys | 1309 | 0.003 | (−0.013 to 0.019) | 1309 | 0.025 | (0.018–0.033) | 1294 | −2.53 | (−3.53 to −1.53) |
| P for interaction | 0.221 | 0.004 | 0.002 | ||||||
CI, confidence interval; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
aDetermined by linear regression analysis adjusted for age, physical activity, body mass index, energy intake, education, diabetes and smoking status as covariates.