TABLE 7.
Cytokine candidate genes and gene polymorphisms evaluated in a Colombian populationa
| Gene | Locus | SNP | rs ID | Location | Predicted functional effect(s) |
|---|---|---|---|---|---|
| IL-1α | 2q13 | −889G>A | rs1800587 | Promoter | TFBS, splicing (ESE or ESS) |
| IL-1β | 2q13 | +3954G>A | rs1143634 | Exon 4 | sSNP, splicing (ESE or ESS) |
| −31G>A | rs1143627 | Promoter | TFBS | ||
| −511G>A | rs16944 | Promoter | TFBS | ||
| IL-10 | 1q31 | −819G>A | rs1800871 | Promoter | TFBS |
| −1082A>G | rs1800896 | Promoter | TFBS | ||
| IFN-γ | 12q24.1 | +874T>A | rs2430561 | Intron 1 | NF-κB binding site |
| TNF-α | 6p21.3 | −308G>A | rs1800629 | Promoter | TFBS |
| −238C>T | rs361525 | Promoter | TFBS | ||
| −863C>A | rs1800630 | Promoter | TFBS | ||
| −857G>A | rs1799724 | Promoter | TFBS | ||
| −1031T>C | rs1799964 | Promoter | TFBS |
a
rs ID, reference SNP ID number; TFBS, transcription factor binding site; ESE, exonic splicing enhancer; ESS, exonic splicing silencer; sSNP synonymous SNP.