Fig. 1.

The organ staining for LacZ expression and the tissue immunohistochemistry staining for IGFBP-3 expression. (A) Rectal administration is the most effective method to express of LacZ in the colon (up; liver, down; colon). (a) Control, (b) intraperitoneal administration, (c) intravenous administration, (d) rectal administration. (B) The immunohistochemistry stain for detecting IGFBP-3 expression shows rectal administration is the most effective method. (a) Control, (b) intraperitoneal administration, (c) intravenous administration, (d) rectal administration (× 200).

IGFBP-3 = insulin-like growth factor-binding protein-3.