Table 3.

Concentration of guanosine-based molecules contained into exosome samples deriving from three different MPC culture of young subjects.

Samples	Concentration (μg mL-1)
	GTP	GDP	GMP	Guanosine
#1 Exosomes from CTR-undiff	nd	nd	nd	nd
#1 Exosomes from CTR-diff	nd	nd	nd	nd
#1 Exosomes from GTP-undiff	nd	0.10 ± 0.01	nd	1.70 ± 0.18
#1 Exosomes from GTP-diff	nd	0.36 ± 0.04	nd	2.52 ± 0.25
#2 Exosomes from CTR-undiff	nd	nd	nd	nd
#2 Exosomes from CTR-diff	nd	nd	nd	nd
#2 Exosomes from GTP-undiff	nd	nd	0.15 ± 0.02	4.17 ± 0.35
#2 Exosomes from GTP-diff	0.33 ± 0.03	0.19 ± 0.01	nd	0.20 ± 0.02
#3 Exosomes from CTR-undiff	nd	nd	nd	nd
#3 Exosomes from CTR-diff	nd	nd	nd	nd
#3 Exosomes from GTP-undiff	nd	nd	nd	1.51 ± 0.12
#3 Exosomes from GTP-diff	0.16 ± 0.02	0.17 ± 0.02	nd	0.70 ± 0.05

nd, not detected. #1, #2, #3 three different young volunteers from whom we obtained myogenic precursor cells. CTR-undiff = the exosomes obtained from the medium conditioned with the human MPC cells in proliferative state for3 days in GM. CTR-diff = the exosomes obtained from the medium conditioned with the human MPC cells in differentiative state for 24 h. GTP-undiff = the exosomes obtained from the medium conditioned with the human MPC cells in proliferative state for additional 24 h after 2 days of regular cultivation in GM. GTP-diff = the exosomes obtained from the medium conditioned with the human MPC cells in differentiative state in presence of 500 μM extracellular GTP for 24 h.