Fig. 4.

IG treated mice show reduced pro-inflammatory cytokines release. ELISA shows IG dampens proinflammatory cytokines secretion in dko treated compared to control mice, data are means ± SE of four animals per group (WT, dko control and dko IG) from two independent experiments (n = 2 mice per group in each one of them), totalizing n = 12 mice analyzed (*p < 0.05; **p < 0.01; ***p < 0.001). TNF-α and IL-1β were measured from DCs culture while IFN-γ and IL-2 were measured in the DC-lymphocytes supernatants co-culture. For TNF-α and IL-1β, white columns represent DCs only and black columns represent DCs activated with muscle antigens