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. 2018 Mar 23;8:5145. doi: 10.1038/s41598-018-23338-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Double deletion of CD9/CD81 results in reduced SIRT1 expression. (a) Immunoblot of the lungs for major aging molecules. Notably, expression of SIRT1, but not that of SIRT6, Klotho, WRN, and ATR, was reduced in DKO lungs. (b) Knockdown of CD9 and CD81 expression with siRNA in epithelial cells additively downregulated the expression of SIRT1. (c) SIRT1 expression by ELISA (n = 4). (d) SIRT1 expression by immunocytochemistry. Bars represent means ± SD; *P < 0.05 versus si-cont. Scale bar, 50 µm for (d).