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. 2018 Mar 23;8:5084. doi: 10.1038/s41598-018-23110-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A pool of 794 putative identified metabolites that were significantly differed (P < 0.05) between samples from control and treatment with pretomanid were mapped on to specific metabolic pathways as defined by KEGG (Kyoto Encyclopaedia of Genes and Genomes). The Sankey diagram shows the relative accumulation of metabolites per pathway. Only pathways where more than three constituent metabolites have been targeted are depicted as discrete pathways. The associated heatmap schematically represents the relative concentration of each metabolite in six replicates of untreated controls and pretomanid-treated (t = 6 h) Mycobacterium smegmatis cultures.