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. 2018 Mar 23;8:5115. doi: 10.1038/s41598-018-23395-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Significance of biological process GO terms over time with annual GO version updates (year of GO version = year of GO annotation version). Development of p-value significance in GO enrichment analysis result term sets in different GO versions are shown for subsets of significantly enriched biological process GO terms (p-value < 0.05 in at least one GO version) in three representative diseases: (A) influenza, (B) non-small cell lung cancer, and (C) pancreatic cancer. Terms belonging to selected top-level branches in the biological process ontology are indicated in color (e.g. cellular process in violet).