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. 2018 Mar 23;8:5115. doi: 10.1038/s41598-018-23395-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of ontology and annotation version on consistency and significance of GO enrichment analysis results. (A) Effect in influenza for the GO term response to interferon-gamma. (B) Number of human genes annotated with the GO term response to interferon-gamma (including all child terms) in influenza gene set vs. background. (C) Comparison of enrichment p-value and information content (IC) developments with annual updates of GO and GO annotations (year of GO version = year of GO annotation version) for response to interferon-gamma in influenza. (D) GO term enrichment significance for cell cycle in non-small cell lung cancer (see Supplementary Figure 8 for pancreatic cancer). (E) Number of human genes annotated with the GO term cell cycle (including child terms) in pancreatic and non-small cell lung cancer gene sets vs. background (human genome). (F) Comparison of enrichment p-value and IC developments with annual updates of GO and GO annotations for cell cycle in pancreatic and non-small cell lung cancer.