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Unsupervised analysis reveals clustering of Kabuki syndrome cases based on variant type. Hierarchical clustering dendrogram, based on the 10% most variably methylated probes (n = 47,130), shows differences in DNA methylation patterns based on type of genetic variation within the histone machinery genes KMT2A and KMT2D. We depict loss of function KMT2D variants in red, KMT2D missense changes in green, and KMT2A missense and splice site variants in blue
