Table 2.
SNP with genome-wide levels of associations for urine z-HP levels in the discovery stage of the study and their corresponding association levels in the validation datasets.
| SNP | Chr | Pos | TA | Discovery stage | Replication stage | Meta-analysis (N = 805) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DN Chinese (N = 236) | DN Malay (N = 57) | SMART2D Chinese (N = 512) | β (SE) | P | P_het | I2 | ||||||||||
| TAF | β (SE) | P | TAF | β (SE) | P | TAF | β (SE) | P | ||||||||
| urine z-HP | ||||||||||||||||
| rs75444904 | 16 | 72095650 | C | 0.307 | 0.732 (0.082) | 1.07 × 10−16 | 0.219 | 0.705 (0.214) | 1.80 × 10−3 | 0.275 | 0.807 (0.059) | 3.98 × 10−41 | 0.777 (0.047) | 1.21 × 10−60 | 0.717 | 0 |
| Plasma z-HP | ||||||||||||||||
| rs75444904 | 16 | 72095650 | C | 0.307 | 0.583 (0.088) | 2.08 × 10−10 | 0.219 | 0.438 (0.251) | 0.087 | NA | NA | NA | 0.567 (0.083) | 6.51 × 10−12 | 0.586 | 0 |
Data analysis was adjusted for age, sex and Principal Components (PC1 for Chinese and PC1–3 for Malay). Abbreviations: Chr, chromosome number; TA, test allele; TAF, test allele frequency, P_het: Cochran’s Q heterogeneity p-value, I2: heterogeneity index, NA: not available.