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. 2018 Mar 23;9:1220. doi: 10.1038/s41467-018-03679-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Relationship between E2 increase and the emotional enhancement of memory contrast. a Statistical t-map of the negative quadratic relationship between salivary Day 1 to Day 2 increase in 17-beta-estradiol (E2) and the emotional enhancement of memory (EEM; hit > miss × negative > neutral) contrast in the right insula (N = 121; FWE-corrected p = .015; t-test). The statistical map is thresholded at FWE-corrected p < .05 (warm color scale) and p_unc < .005 (cold color scale) for visualization purposes. b Robust regression analysis between contrast estimates (y-axis) and salivary E2 increase (x-axis) confirmed the inverted U-shaped relationship. Difference in Bayesian Information Criterion (ΔBIC) between the linear and quadratic model was 16.9, strongly evidencing a better model fit of the quadratic compared to the linear model. Colors represent experimental groups