. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: Lancet Child Adolesc Health. 2017 Oct 20;1(4):293–301. doi: 10.1016/S2352-4642(17)30122-0

Table 3.

Multivariable regression models of proinflammatory cytokines, catecholamines and cortisol for long-term outcomes

	Long-term event

	EF < 50%		EF < 40%		E/e′ > 8		avcIB

	Estimate	p	Estimate	p	Estimate	p	Estimate	p
Model [IL-1b, TNFα, IL-6, IL-8]
Acute, maximum concentration
Intercept	−0.98	0.212			−2.12	0.223	−1.97	0.0502
IL-1P	0.0183	0.556			0.00266	0.651	−0.0897	0.204
IL-6	0.00144	0.193			−0.000452	0.554	0.00141	0.0407
IL-8	−0.000487	0.299			0.0168	0.0542	^#	^#
TNFα	0.0156	0.392			−0.0169	0.408	−0.00367	0.221

R²	0.438	0.0232			0.596	0.00159	0.427	0.0267

Model [IL-1b, TNFα, IL-6, IL-8]
Acute, mean concentration
Intercept	−2.08	0.0506	−2.09	0.0384	−3.28	0.0867
IL-1β	0.055	0.544	−0.0467	0.116	−0.00811	0.824
IL-6	−0.000432	0.114	−0.00138	0.502	0.000419	0.867
IL-8	0.00525	0.754	^#	^#	0.0381	0.0196
TNFα	0.121	0.122	0.167	0.0311	−0.024	0.728

R²	0.494	0.0063	0.356	0.0299	0.633	< 0.0001

Model [epinephrine, cortisol]
Acute, mean concentration
Intercept	0.257	0.805	−0.536	0.67
Epinephrine	0.00814	0.401	0.0104	0.448
Cortisol	−0.00511	0.211	−0.00547	0.327

R²	0.683	0.0499	0.631	0.0293

= Modeled without IL-8. Epinephrine and cortisol concentrations per 24h in urine, averaged over duration of acute hospitalization.