Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 9;131(12):1360–1371. doi: 10.1182/blood-2017-09-800326

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by The American Society of Hematology

PMC Copyright notice

Figure 2. — Murine models of thrombosis. (A-C) TF-induced venous thromboembolism in F8^+/+ Pros1^+/+, F8^−/− Pros1^+/+, F8^−/− Pros1^+/−, and F8^−/− Pros1^−/− mice (n = 10 per genotype). Anesthetized mice were injected intravenously via the inferior vena cava with different doses of recombinant TF (Innovin): 1/2 dilution (∼4.3 nM TF) in panel A and 1/4 dilution (∼2.1 nM TF) in panels B-C. In panel A, one group of F8^+/+Pros1^+/+ mice received an injection of the low molecular weight heparin (enoxaparin 60 µg/g s.c.). The time to onset of respiratory arrest that lasted at least 2 minutes was recorded. Experiments were terminated at 20 minutes. Kaplan-Meier survival curves (A-B). (C) Two minutes after onset of respiratory arrest or at the completion of the 20-minute observation period, lungs were excised and investigated for fibrin clots (indicated by arrowheads, immunostaining for insoluble fibrin, monoclonal antibody clone 102-10) Scale bars: 200 μm. (D) Thrombus formation in FeCl₃-injured mesenteric arteries recorded by intravital microscopy in F8^+/+ Pros1^+/+, F8^−/− Pros1^+/+, and F8^−/− Pros1^−/− mice, representative experiment (n = 3 per genotype).