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Normal cells have lower ROS content and the ROS level increases in cancer cells for inducing tumorigenesis. Anticancer agents induce apoptosis through ROS generation and prolonged treatment reduces ROS to make the cells resistant to drugs. Exogenous ROS with the drug again sensitizes resistant cells and kills through apoptosis. ROS, reactive oxygen species. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
