Table 3.

Biodistribution of ⁶⁴Cu-CB-TE2A-c(RGDyK), ⁶⁴Cu-AP-c(RGDyK), and ⁶⁴Cu-KP-c(RGDyK) in Nontumor-Bearing BALB/c Female Mice at 1, 2, 4, and 24 H Postinjection

	64Cu-CB-TE2A-c(RGDyK)				64Cu-AP-c(RGDyK)				64Cu-KP-c(RGDyK)
Organ	1 h	2 h	4 h	24 h	1 h	2 h	4 h	24 h	1 h	2 h	4 h	24 h
Blood	0.14 ± 0.001	0.006 ± 0.008	0.005 ± 0.001	0.005 ± 0.002	0.08 ± 0.02	0.10 ± 0.03	0.03 ± 0.02	0.03 ± 0.01	0.10 ± 0.01	0.06 ± 0.01	0.05 ± 0.04	0.03 ± 0.01
Lung	0.51 ± 0.13	0.63 ± 0.07	0.56 ± 0.11	0.52 ± 0.29	0.57 ± 0.11	0.55 ± 0.16	0.29 ± 0.22	0.32 ± 0.15	0.41 ± 0.33	0.63 ± 0.37	0.49 ± 0.07	0.83 ± 0.48
Liver	1.21 ± 0.19	2.06 ± 0.22	2.28 ± 0.53	1.02 ± 0.13	0.64 ± 0.58	1.08 ± 0.39	0.73 ± 0.60	0.43 ± 0.22	0.77 ± 0.03	0.99 ± 0.29	0.94 ± 0.17	1.25 ± 0.78
Spleen	0.81 ± 0.09	1.39 ± 0.10	1.22 ± 0.38	1.32 ± 0.32	0.86 ± 0.13	1.12 ± 0.19	0.60 ± 0.48	0.94 ± 0.32	0.71 ± 0.05	1.04 ± 0.29	1.01 ± 0.08	0.90 ± 0.08
Kidney	1.88 ± 0.40	3.17 ± 0.13	3.01 ± 0.10	1.38 ± 0.49	1.39 ± 0.19	1.77 ± 0.46	1.50 ± 0.52	0.93 ± 0.38	1.56 ± 0.09	1.62 ± 0.14	1.71 ± 0.17	2.56 ± 0.79
Muscle	0.12 ± 0.01	0.10 ± 0.04	0.13 ± 0.003	0.10 ± 0.03	0.13 ± 0.01	0.13 ± 0.01	0.13 ± 0.01	0.13 ± 0.003	0.13 ± 0.01	0.12 ± 0.01	0.14 ± 0.01	0.13 ± 0.06
Heart	0.21 ± 0.02	0.21 ± 0.07	0.33 ± 0.12	0.29 ± 0.17	0.26 ± 0.03	0.27 ± 0.06	0.12 ± 0.09	0.16 ± 0.07	0.24 ± 0.03	0.51 ± 0.52	0.26 ± 0.01	0.56 ± 0.23
Stomach	0.37 ± 0.05	0.43 ± 0.07	0.56 ± 0.19	0.22 ± 0.05	0.28 ± 0.09	0.50 ± 0.11	0.28 ± 0.18	0.23 ± 0.08	0.27 ± 0.05	0.52 ± 0.26	0.36 ± 0.10	0.97 ± 0.5
Sm int	0.82 ± 0.17	1.26 ± 0.20	1.00 ± 0.06	0.25 ± 0.05	0.55 ± 0.19	0.77 ± 0.24	0.53 ± 0.28	0.45 ± 0.15	0.67 ± 0.04	0.72 ± 0.14	0.78 ± 0.25	0.97 ± 0.57
Lg int	0.44 ± 0.04	2.16 ± 0.44	2.11 ± 0.63	0.19 ± 0.23	0.41 ± 0.11	1.36 ± 0.10	0.88 ± 0.38	0.32 ± 0.15	0.34 ± 0.08	0.73 ± 0.23	1.13 ± 0.61	1.05 ± 0.69

Values are expressed as %ID/g (n = 3).