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. 2018 Mar 16;9:226. doi: 10.3389/fphar.2018.00226

FIGURE 3.

FIGURE 3

ISL pretreatment induced expressions of (A) MRP2, (B) MRP4, and (C) P-gp to protect against TP-induced cytotoxicity. L02 cells were treated with 50 nM TP with or without 2.5, 5, and 7.5 μM ISL pretreatment. The tert-butylhydroquinone (15 μM) was used as an Nrf2 inducer. RT-PCR was used to analyze mRNAs and proteins by Western blot. Data were presented as means ±SE (n = 3);∗∗∗P < 0.001 vs. the control group, ##P < 0.01 vs. the TP group, and ###P < 0.001 vs. the TP group.