Table 2.
Allele and genotype distributions of rs11129295 between MS and healthy controls
| SNP | Region | Candidate Gene | Genotype/Allele | MS, n (%) | HC, n (%) | χ2 | OR (95% CI) | P |
|---|---|---|---|---|---|---|---|---|
| Stage 1 | ||||||||
| rs11129295 | Intergenic | EOMES | TT | 91 (65.9) | 157 (52.2) | 10.251 | 0.005 | |
| CT | 44 (31.9) | 119 (39.5) | ||||||
| CC | 3 (2.2) | 25 (8.3) | ||||||
| T | 226 (81.9) | 433 (71.9) | 10.022 | 1.764 (1.238–2.514) | 0.002 | |||
| C* | 50 (18.1) | 169 (28.1) | ||||||
| CT + TT† | 135 (97.8) | 276 (91.7) | 5.958 | 4.076 (1.209–13.739) | 0.019 | |||
| CC | 3 (2.2) | 25 (8.3) | ||||||
| TT‡ | 91 (65.9) | 157 (52.2) | 7.313 | 1.776 (1.169–2.769) | 0.007 | |||
| CT + CC | 47 (34.1) | 144 (47.8) | ||||||
| Stage 2 | ||||||||
| rs11129295 | Intergenic | EOMES | TT | 26 (59.1) | 97 (48.5) | 6.336 | 0.020 | |
| CT | 18 (40.9) | 78 (39) | ||||||
| CC | 0 (0) | 25 (12.5) | ||||||
| T | 70 (79.5) | 272 (68.0) | 4.586 | 1.830 (1.046–3.200) | 0.030 | |||
| C* | 18 (20.5) | 128 (32.0) | ||||||
| CT + TT† | 44 (100) | 175 (87.5) | 6.128 | 1.143 (1.085–1.204) | 0.011 | |||
| CC | 0 (0) | 25 (12.5) | ||||||
| TT‡ | 26 (59.1) | 97 (48.5) | 1.618 | 1.534 (0.791–2.973) | 0.203 | |||
| CT + CC | 18 (40.9) | 103 (51.5) | ||||||
| Stage 1 + 2 | ||||||||
| rs11129295 | Intergenic | EOMES | TT | 117 (64.3) | 254 (50.7) | 17.452 | 4.17×10−5 | |
| CT | 62 (34.1) | 197 (39.3) | ||||||
| CC | 3 (1.6) | 50 (10.0) | ||||||
| T | 296 (81.3) | 705 (70.4) | 16.378 | 1.834 (1.363–2.466) | 5.19×10−5 | |||
| C* | 68 (18.7) | 297 (29.6) | ||||||
| CT + TT† | 179 (98.4) | 451 (90.0) | 12.947 | 6.615 (2.037–21.481) | 8.12×10−5 | |||
| CC | 3 (1.6) | 50 (10.0) | ||||||
| TT‡ | 117 (64.3) | 254 (50.7) | 9.932 | 1.750 (1.233–2.484) | 0.002 | |||
| CT + CC | 65 (35.7) | 247 (49.3) |
*The C allele is the ancestral allele according to dbSNP build 141; †Analysis in a dominant model; ‡Analysis in a recessive model. SNP: Single-nucleotide polymorphisms; MS: Multiple sclerosis; HC: Healthy controls. CI: Confidence interval; OR: Odds ratio.