Table 3.
Differences in CSF PfHRP-2 and plasma PfHRP-2 levels by finding for 58 patients with brain magnetic resonance imaging
| Radiographic finding | N (%) positive | Plasma PfHRP-2, median (IQR) | CSF PfHRP-2, median (IQR) | ||||
|---|---|---|---|---|---|---|---|
| Positive finding | Negative finding | p valuea | Positive finding | Negative finding | p valuea | ||
| Frontal–occipital lobe T2 hyperintensity | 6 (10) | 37.9 (13.7–65.7) | 24.3 (8.5–51.1) | 0.72 | 5782 (2602–21,100) | 12,906 (4820–22,569) | 0.35 |
| Periventricular T2 hyperintensity | 25 (43) | 15.2 (0.6–36.4) | 31.6 (14.8–65.3) | 0.03 | 11,000 (4258–17,510) | 15,094 (5573–28,084) | 0.17 |
| Periventricular DWI abnormality | 22 (38) | 17.7 (8.8–33.3) | 32.6 (8.1–64.8) | 0.25 | 9951 (3631–19,172) | 14,226 (5542–26,893) | 0.27 |
| Subcortical white matter T2 hyperintensity | 39 (67) | 24.7 (13.5–63.7) | 30.1 (2.8–48.1) | 0.90 | 11,000 (5294–21,100) | 16,099 (3968–26,906) | 0.80 |
| Cortical T2 hyperintensity | 47 (81) | 27.9 (9.9–48.2) | 14.2 (3.8–96.1) | 0.77 | 13,358 (5294–26,879) | 10,242 (3595–17,533) | 0.20 |
| Cortical DWI abnormality | 6 (10) | 5.0 (0–27.9) | 27.7 (13.6–64.0) | 0.06 | 14,754 (1678–28,084) | 11,847 (5403–20,136) | 0.69 |
| Caudate T2 hyperintensity | 41 (71) | 29.1 (13.5–64.3) | 15.2 (8.2–43.0) | 0.31 | 13,358 (5862–26,879) | 8147 (3968–17,533) | 0.13 |
| Caudate DWI abnormality | 4 (7) | 69.0 (18.5–212.0) | 24.3 (8.8–48.2) | 0.23 | 15,390 (11,047–26,981) | 11,184 (4274–22,110) | 0.51 |
| Globus pallidi T2 hyperintensity | 43 (74) | 30.1 (13.5–65.3) | 14.8 (6.2–35.1) | 0.11 | 15,094 (5863–26,906) | 5512 (3968–17,533 | 0.49 |
| Globus pallidi DWI abnormality | 13 (22) | 65.3 (26.3–92.7) | 19.2 (8.2–46.3) | 0.02 | 15,094 (11,000–36,540) | 10,470 (4258–21,100) | 0.09 |
| Putamen T2 hyperintensity | 42 (72) | 29.6 (13.5–64.3) | 15.0 (5.5–39.0) | 0.19 | 14,783 (5662–26,906) | 6830 (2830–16,816) | 0.04 |
| Putamen DWI abnormality | 7 (12) | 63.7 (13.7–101.6) | 23.8 (8.2–48.1) | 0.11 | 13,358 (10,242–36,540) | 11,128 (4258–22,110) | 0.28 |
| Thalamus T2 hyperintensity | 31 (53) | 26.3 (8.8–48.2) | 19.2 (8.2–65.7) | 0.99 | 13,358 (3902–26,906) | 11,000 (5512–17,732) | 0.61 |
| Corpus callosum T2 hyperintensity | 20 (34) | 22.4 (13.7–44.6) | 29.0 (2.8–64.3) | 0.85 | 13,852 (5434–21,605) | 11,847 (4258–26,906) | 0.921 |
| Corpus callosum DWI abnormality | 19 (33) | 24.7 (13.7–46.3) | 27.9 (2.8–64.3) | 0.86 | 17,462 (5573–23,028) | 11,240 (3968–18,048) | 0.49 |
| Posterior fossa T2 hyperintensity | 34 (59) | 30.3 (13.5–64.3) | 17.2 (4.5–47.9) | 0.29 | 17,486 (5992–28,084) | 8442 (4113–16,760) | 0.02 |
| Posterior fossa DWI abnormality | 4 (7) | 50.7 (4.4–207.6) | 25.5 (9.9–48.2) | 0.74 | 7526 (852–14,226) | 11,847 (5294–23,028) | 0.14 |