Fig. 3.

TLR3 deficiency decreases cocaine self-administration. a WT mice exhibit stronger cocaine-seeking behavior than TLR3-knockout mice after 4 sessions. *p < 0.05, n = 7/WT group, n = 7/TLR3KO group. b TLR3 knockout mice have no significant difference in saline self-administration compared to WT mice, n = 7/WT group, n = 7/TLR3KO group. c WT mice show significantly different cocaine intake compared to TLR3 deficient mice after 4 sessions, *p < 0.05, n = 7/WT group, n = 7/TLR3 KO group. Data are presented as the mean ± SEM