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. 2018 Mar 23;15:93. doi: 10.1186/s12974-018-1130-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Inhibition of TLR3 weakens cocaine-induced CPP and locomotor activity in wide-type mice. a Intra-NAc TLR3/dsRNA complex inhibitor (50 μM, 1 μl/injection) attenuates cocaine CPP (20 mg/kg). **p < 0.01, n = 16/DMSO+CO group, n = 17/inhibitor+CO group, n = 16/DMSO+SA group, n = 16/inhibitor+SA group. b, c Group mean total distance traveled in centimeters in the 15 mins after cocaine administration every day (20 mg/kg/day). DMSO control group showed greater locomotor activity than the inhibitor group over all injection days. ***p < 0.001, n = 13/DMSO+CO group, n = 13/inhibitor+CO group, n = 10/DMSO+SA group, n = 11/inhibitor+SA group. Cocaine (CO), saline (SA). Data are presented as the mean ± SEM