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. 2018 Mar 23;20:57. doi: 10.1186/s13075-018-1541-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue, methotrexate (MTX) add-on (a) and monotherapy (b) studies. P values given for pair-wise comparison with placebo: *p < 0.05; **p < 0.01; ***p < 0.001. At week 12, patients receiving placebo in the MTX add-on study and patients receiving placebo and filgotinib 50 mg once daily (q.d.) in the monotherapy study who had not achieved a 20% improvement in swollen joint count (SJC) and tender joint count (TJC) were reassigned to receive filgotinib 100 mg q.d. (both studies) or 50 mg twice daily (b.i.d.) (MTX add-on study only). Patients who switched treatments at week 12 were handled as discontinuations and data were imputed from week 12 onwards using last observation carried forward. SE, standard error