Table 1.
Shortlist of the selected genesa
| Associated gene | discription | DMR position | DMR Distance from TSS | DMCs number | Methylation difference (Tumor -Normal) | Gene expression (Tumor / Normal) | |
|---|---|---|---|---|---|---|---|
| ratio | p-value | ||||||
| downstream | |||||||
| Slpi | secretory leukocyte protease inhibitor | chr2: 164355520–164,355,812 | + 697 | 9 | −33.83 | 408.37 | 0.0090 |
| Cela1 | chymotrypsin-like elastase family, member 1 | chr15: 100687184–100,687,240 | + 682 | 3 | −31.23 | 71.51 | 0.0003 |
| Mst1r | macrophage stimulating 1 receptor | chr9: 107908081–107,908,516 | + 1192 | 13 | −46.34 | 67.47 | 0.0005 |
| Btg2 | B cell translocation gene 2 | chr1: 134077506–134,077,566 | + 1591 | 3 | −46.61 | 18.30 | 0.0050 |
| Fgl2 | fibrinogen-like protein 2 | chr5: 21373036–21,373,583 | + 366 | 10 | −31.73 | 11.88 | 0.0002 |
| P2rx7 | purinergic receptor P2X | chr5: 122644473–122,644,655 | + 562 | 4 | −43.12 | 8.23 | 0.0031 |
| Lss | lanosterol synthase | chr10: 76532531–76,532,879 | + 904 | 8 | −59.93 | 6.17 | 0.0000 |
| Grhl1 | grainyhead-like 1 | chr12: 24573292–24,573,626 | + 1005 | 3 | −39.22 | 6.06 | 0.0020 |
| Itm2c | integral membrane protein 2c | chr1: 85895741–85,895,786 | + 1231 | 3 | −31.78 | 3.91 | 0.0015 |
| Chmp6 | charged multivesicular body protein 6 | chr11: 119915542–119,915,667 | + 1732 | 6 | −53.11 | 2.88 | 0.0002 |
| Vasp | vasodilator-stimulated phosphoprotein | chr7: 19269155–19,269,927 | + 1929 | 14 | −40.96 | 2.27 | 0.0016 |
| Mmp14 | matrix metallopeptidase 14 | chr14: 54433543–54,434,231 | + 1939 | 13 | −39.11 | 2.19 | 0.0012 |
| Marveld2 | MARVEL domain containing 2 | chr13: 100615630–100,615,803 | + 1143 | 2 | −34.10 | 2.06 | 0.0238 |
| Pdk2 | pyruvate dehydrogenase kinase, isoenzyme 2 | chr11: 95039447–95,039,657 | + 1716 | 7 | 38.16 | 0.48 | 0.0034 |
| Extl1 | exostoses-like 1 | chr4: 134371099–134,371,620 | + 929 | 44 | 48.12 | 0.39 | 0.0216 |
| Grm8 | glutamate receptor, metabotropic 8 | chr6: 28133156–28,133,165 | + 1206 | 3 | 33.66 | 0.32 | 0.0016 |
| Ppp1r14a | protein phosphatase 1, regulatory inhibitor subunit 14A | chr7: 29291240–29,291,527 | + 1920 | 8 | 36.03 | 0.25 | 0.0052 |
| Snx29 | sorting nexin 29 | chr16: 11405750–11,405,827 | + 102 | 3 | 60.92 | 0.22 | 0.0218 |
| C8b | complement component 8, beta polypeptide | chr4: 104767260–104,767,325 | + 943 | 7 | 54.51 | 0.18 | 0.0066 |
| Igfals | insulin-like growth factor binding protein, acid labile subunit | chr17: 24880338–24,882,131 | + 1568 | 57 | 38.73 | 0.17 | 0.0003 |
| Adam11 | a disintegrin and metallopeptidase domain 11 | chr11: 102762268–102,762,503 | + 829 | 16 | 54.16 | 0.16 | 0.0002 |
| Cyp8b1 | cytochrome P450, family 8, subfamily b, polypeptide 1 | chr9: 121914943–121,915,025 | + 1279 | 6 | 63.26 | 0.10 | 0.0231 |
| Upstream | |||||||
| Ltb | lymphotoxin B | chr17: 35194367–35,194,502 | −4 | 3 | −32.55 | 20.94 | 0.0410 |
| Nfe2 | nuclear factor, erythroid derived 2 | chr15: 103259509–103,259,588 | − 1105 | 4 | −36.04 | 12.39 | 0.0045 |
| Hmgcr | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | chr13: 96671738–96,671,790 | − 801 | 1 | −30.40 | 4.80 | 0.0144 |
| Slc29a1 | solute carrier family 29 member 1 | chr17: 45600404–45,600,454 | − 800 | 2 | 37.50 | 0.37 | 0.0010 |
| Slc17a8 | solute carrier family 17 | chr10: 89621306–89,622,039 | −60 | 7 | 51.72 | 0.11 | 0.0142 |
aThese genes are hit by PubMed search for the term “cancer” and whose expressions are up- or down-regulated more than 2-fold in an inverse manner compared to the methylation rates between the normal and tumor tissues. Chr: chromosome, DMR: differentially methylated region, DMC: differentially methylated cytosine, TSS: transcription start site. P-values were analyzed by Student’s t-test