Table 1.
The comparison of NO signaling pathway, some bone formation and degradation markers, cortisol and some oxidative stress parameter values in rats with glucocorticoid-induced osteoporosis.
| Control | DEX | DEX + Zaprinast | DEX + Avanafil | |
|---|---|---|---|---|
| eNOS (ng/mL) | 51.804±0.333 | 56.038±0.660* | 56.460±0.500* | 56.279±0.421* |
| NO (μmol/L) | 186.554±2.290 | 202.109±3.394* | 196.561±3.966# | 199.212±3.522# |
| PDE-5 (ng/mL) | 5.247±0.046 | 5.038±0.377 | 4.656±0.605# | 3.877±0.554#,@ |
| cGMP (pmol/L) | 37.901±0.440 | 40.752±0.645* | 42.515±0.348# | 45.481±0.511#,@ |
| PKG (ng/mL) | 11.821±0.164 | 11.744±0.161 | 11.914±0.238 | 14.710±0.332@ |
| PICP (ng/mL) | 68.105±0.781 | 72.595±0.434* | 63.625±0.317# | 62.897±0.724# |
| CTCP (ng/mL) | 5.668±0.026 | 5.702±0.061 | 5.813±0.058# | 6.389±0.023@ |
| Cortisol (ng/L) | 92.817±2.872 | 42.742±2.685* | 41.282±1.731* | 46.037±3.712* |
| MDA (μM) | 1.702±0.047 | 2.150±0.124* | 2.006±0.101# | 1.980±0.104# |
| CoQ10/CoQ10H | 0.301±0.032 | 0.402±0.026* | 0.331±0.044 | 0.332±0.029 |
| 8-OHdG/106dG | 0.666±0.097 | 0.831±0.073* | 0.500±0.094# | 0.486±0.095# |
*
When compared to the control group in each line (p<0.05).
#
When compared to the control and DEX groups in each line (p<0.05).
@
When compared to the other groups in each line (p<0.05).
eNOS – endothelial nitric oxide synthase; NO – nitric oxide; PDE-5 – phosphodiesterase-5; cGMP – cylic guanosine mono phosphate; PKG – protein kinase G; PICP – procollagen peptide; CTCP – cterminal collagen peptide; MDA – malondialdehyde; CoQ10 – ubiquinone 10; 8-OHdG – 8-hydroxy-2-deoxyguanosine; dG – deoxyguanosine.