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. 2017 Dec 21;103(4):575–586. doi: 10.3324/haematol.2017.176370

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Figure 6. — Regulation of EPOR signaling and positions of the EPOR truncations. (A) Negative regulators of EPOR signaling and their binding sites in the C-terminal part of the receptor: negative signaling regulators (on the left) and internalization/degradation sites (on the right). The tyrosine (Y) number of the mature EPOR is also indicated in parentheses. (B) Proximal truncations due to EPOR p.Glu399* and p.Glu425* lack all negative regulation sites of the receptor. (C and D) More distal truncations due to frameshift EPOR mutants and their designed counterparts retain the Tyr-426.