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. 2018 Jan 25;103(4):597–606. doi: 10.3324/haematol.2017.181958

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Figure 2. — Ob/Ob mice display prolonged survival when challenged with myelodysplastic syndrome despite preexisting monocytosis. Ob/Ob mice and WT littermate controls transplanted with either WT or NHD13 BM were followed for (A) Kaplan-Meier survival curve. (B) Proportion of disease contributing to death. Circulating myeloid cell populations, including (C) total monocytes, (D) Ly-6C^hi monocytes, (E) Ly-6C^lo monocytes and (F) neutrophils analyzed by flow cytometry on lysed blood. Circulating lymphoid populations, including (G) B cells and (H) T cells analyzed by flow cytometry on lysed blood. (A,B); n=16; (C–H); n=12–16. All data expressed as mean ± SEM. WT: wild-type; MDS: myelodysplastic syndrome; T-ALL: T-cell acute lymphoblastic leukemia; CMML: chronic myelomonocytic leukemia; AML: acute myeloid leukemia; BMT: bone marrow transplant.