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. 2018 Feb 15;103(4):666–678. doi: 10.3324/haematol.2017.182048

Figure 3.

Figure 3.

Identification of functionally related clusters of genes by Gene Set Enrichment Analysis leading edge analysis. Heatmaps showing clustering of functional categories and leading edge genes that are up-regulated (A) or down-regulated (B) in adherent Jeko-1 cells relative to suspension of Jeko-1 cells in co-cultures. The numbers of leading edge genes and functional categories are shown in each panel: 24 clusters (c1-c24), defined as having ≥10 genes and ≥1 functional categories, were identified (see Table 2 for more details). Four additional groups of genes that contain many functional categories but which do not fulfill the cluster criteria are denoted i–iv.