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. 2018 Feb 26;8(2):2045893218757596. doi: 10.1177/2045893218757596

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 3. — Schematic representation of central adhesion molecules mediating rolling and firm adhesion of circulating leukocytes on the vascular endothelium. Rolling is mediated by interaction of endothelial E- and P-selectin with L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) on the surface of the leukocyte, while firm adhesion involves interaction of endothelial intercellular adhesion molecule (ICAM)-1 with α_Lβ₂ (lymphocyte function-associated antigen 1 [LFA-1]) or α_Mβ₂ (macrophage-1 antigen [MAC-1]) integrin, or interaction of vascular cell adhesion molecule 1 (VCAM-1; CD106) with α₄β₁ integrin (very late antigen 4 [VLA-4]) on the leukocyte.