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. 2018 Feb 26;8(2):2045893218755987. doi: 10.1177/2045893218755987

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Immunohistochemical staining of the lung tissues for candidate proteins in each group. A0–A2: caveolin-1 expression in the lung tissue of each group, B0–B2: FLNA expression in the lung tissue of each group, C0–C2: cathepsin D expression in the lung tissue of each group, D0–D2: GSTM1 expression in the lung tissue of each group. 0, 1, 2 represent the normal, reversible CHD-PAH, and irreversible CHD-PAH groups, respectively. Caveolin-1, FLNA, and cathepsin D were significantly upregulated and GSTM1 was downregulated expression in the irreversible CHD-PAH group, compared to the reversible and control groups. These tendencies were also significant between the reversible CHD-PAH group and control group.