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H-AGE intake led to inferior microstructure of cortical vertebrae in 18-month-old mice. (A) 3D μCT images of Ct bone for (top) 6-month-old and (bottom) 18-month-old mice. H-AGE diet decreased (B) Ct.BMD in 18-month-old mice; (C) Ct.Th decreased with age, and aging effects dominated any potential diet effects. *p < 0.05, **p < 0.001. mo = months; Ct = cortical; Ct.BMD = cortical bone mineral density; Ct.Th = cortical thickness.
