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H-AGE diet led to lower Tb bone moduli in 6-month-old female mice with significantly lower (A) shear modulus and (B) compression modulus along the principal Tb axis that were calculated from an anisotropic model in the direction of the principal trabecular axis. Moduli were computed considering effects of mass density, porosity, and structural directionality. *p < 0.05, **p < 0.001. mo = months; Tb = trabecular.
