Table 6. Trabecular and Cortical Bone Quantity and Quality From μCT Analysis.
| 6 months | 18 months | 6 versus 18 months (p) | |||||||||||||||
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| L-AGE | H-AGE | P | L-AGE | H-AGE | P | L-AGE | H-AGE | P | L-AGE | H-AGE | P | L-AGE | H-AGE | L-AGE | H-AGE | ||
| Trabecular | Tb.Th (mm) | 0.58 ±0.01 | 0.56 ±0.01 | 0.607 | 0.06 ±0.01 | 0.06 ± 0.01 | 0.513 | 0.056 ±0.01 | 0.06 ±0.01 | >0.99 | 0.06 ± 0.06 | 0.06 ±0.01 | >0.99 | 0.42 | 0.277 | 0.032 | >0.99 |
| Tb.N (1/mm) | 3.65 ±0.24 | 3.37 ±0.40 | 0.337 | 4.42 ±0.18 | 4.12 ±0.64 | >0.99 | 2.34 ±0.73 | 2.12 ±0.56 | 0.001 | 3.30 ±0.55 | 3.21 ±0.66 | >0.99 | 0.001 | 0.001 | 0.001 | 0.015 | |
| Tb.Sp (mm) | 0.25 ±0.01 | 0.27 ±0.03 | 0.311 | 0.19±0.01 | 0.20 ± 0.04 | >0.99 | 0.39 ± 0.08 | 0.40 ± 0.07 | >0.99 | 0.23 ± 0.04 | 0.24 ± 0.03 | >0.99 | 0.001 | 0.001 | 0.001 | 0.051 | |
| Tb.BS/BV (mm−1) | 57.11 ±2.85 | 60.10 ±2.97 | 0.135 | 58.92 ±3.27 | 56.87 ±5.36 | >0.99 | 57.16 ±3.88 | 59.15 ±3.06 | 0.737 | 55.67 ±4.36 | 57.66 ±5.52 | >0.99 | >0.99 | >0.99 | 0.179 | >0.99 | |
| Tb.DA ([]) | 2.10±0.17 | 2.05 ±0.13 | >0.99 | 2.34 ±0.15 | 2.30 ±0.15 | >0.99 | 2.02 ±0.12 | 2.03 ±0.26 | >0.99 | 2.04 ±0.19 | 2.02 ± 0.20 | >0.99 | >0.99 | >0.99 | 0.001 | 0.006 | |
| Tb.TMD (g HA/cm3) | 0.90 ± 0.03 | 0.87 ± 0.02 | 0.542 | 0.88 ± 0.03 | 0.89 ±0.01 | 0.984 | 0.92 ± 0.03 | 0.90 ± 0.04 | 0.525 | 0.93 ± 0.03 | 0.92 ± 0.04 | >0.99 | 0.091 | 0.184 | 0.004 | 0.004 | |
| Tb.BW/TV (%) | 21.11 ± 1.56 | 18.84 ±2.40 | 0.096 | 24.80 ± 2.25 | 24.60 ± 4.98 | >0.99 | 14.16 ±4.54 | 12.49 ±3.57 | >0.99 | 20.28 ±4.25 | 18.93 ±4.30 | >0.99 | 0.001 | 0.001 | 0.001 | 0.045 | |
| Tb.BMD (gm/cm3) | 0.25 ±0.02 | 0.23 ±0.02 | 0.022 | 0.28 ±0.03 | 0.28 ±0.05 | >0.99 | 0.19 ±0.05 | 0.16 ±0.03 | >0.99 | 0.25 ± 0.04 | 0.24 ± 0.04 | >0.99 | 0.002 | 0.001 | >0.99 | 0.090 | |
| Cortical | Ct.BS/BV (mm−1) | 35.41 ±1.85 | 37.41 | 0.21 | 40.34 ±2.21 | 38.45 ±2.61 | 0.384 | 40.84 ±2.59 | 40.54 ± 2.64 | >0.99 | 43.75 ±3.51 | 44.94 ± 3.09 | >0.99 | 0.377 | 0.001 | 0.026 | 0.001 |
| Ct.TMD (g HA/cm3) | 1.06 ±0.41 | 1.04 ± 0.03 | 0.95 | 1.01 ±0.05 | 1.02 ± 0.02 | >0.99 | 1.04 ± 0.02 | 1.00 ±0.02 | 0.002 | 1.04 ± 0.02 | 0.10 ±0.02 | 0.011 | 0.561 | 0.004 | 0.284 | 0.277 | |
| Ct.BMD (gm/cm3) | 1.05 ± 0.04 | 1.04 ± 0.02 | >0.99 | 1.00 ± 0.05 | 1.02 ± 0.02 | >0.99 | 1.03 ± 0.02 | 1.00 ±0.22 | 0.002 | 1.02 ± 0.03 | 0.99 ± 0.04 | 0.024 | >0.99 | 0.001 | >0.99 | >0.99 | |
| Ct.Th (mm) | 0.07 ± 0.00 | 0.07 ±0.01 | >0.99 | 0.06 ± 0.00 | 0.06 ± 0.00 | >0.99 | 0.06 ± 0.00 | 0.06 ±0.01 | >0.99 | 0.07 ±0.01 | 0.06 ± 0.00 | >0.99 | 0.001 | 0.07 | >0.99 | 0.02 | |
| TLAr (mm2) | 0.35 ±0.03 | 0.34 ± 0.04 | >0.99 | 0.29 ±0.02 | 0.31 ±0.03 | >0.99 | 0.34 ± 0.03 | 0.32 ± 0.04 | >0.99 | 0.32 ±0.02 | 0.32 ± 0.02 | >0.99 | >0.99 | >0.99 | 0.009 | >0.99 | |
Values are mean ± SD. Bold values are significant.
L-AGE = low level of advanced glycation end-products; H-AGE = high level of advanced glycation end-products; Tb.Th = trabecular thickness; Tb.N = trabecular number; Tb.Sp = trabecular separation; Tb.BS/BV = trabecular bone surface to volume ratio; Tb.DA = trabecular degree of anisotropy; Tb.TMD = trabecular tissue mineral density; Tb.BMD = trabecular bone mineral density; Tb.BV/TV = trabecular bone volume density; Ct.BS/BV = cortical bone surface to volume ratio; Ct.TMD = cortical tissue mineral density; Ct.BMD = cortical bone mineral density; Ct.Th = cortical thickness; Tt.Ar = cortical total area.