TABLE 1. Key Assumptions Used to Construct Cost-effectiveness Model.

Assumption	Description
1	Patients can experience up to 2 PSCs during the 1-y time horizon
2	PSCs occur either on d 42 (the middle of the first 12-wk period) or on d 224 (the midpoint of wk 12-52 of the 1-y time horizon)
3	Only patients who experience a PSC on d 42 can experience a second PSC during the 1-y time horizon
4	65% of initial PSCs occur on d 42; the remaining 35% of initial PSCs occur on d 224 (ie, the model assumes that patients have a higher likelihood of PSC development relatively early following stoma creation)
5	Increases in use of PSC-related pouching supplies and accessories last from PSC onset until PSC resolution
6	Time to PSC resolution is dependent on its severity
7	Patients who experience a PSC can add accessories to their daily regimen following PSC resolution if they are not already using accessories at PSC onset
8	Costs of accessories added after PSC resolution are incurred from the date of resolution until the end of the model time horizon
9	Irrespective of PSC occurrence, switching from CIB to SoC or vice versa is not allowed

Abbreviations: CIB, ceramide-infused skin barrier; PSC, peristomal skin complication; SoC, standard of care.