TABLE 4. Incidence and Severity of PSCs^a.

Parameter	SoC	CIB
Annual probability of PSC	55% (41/74)	41% (32/79)
Proportion of patients who experience a second PSC, among patients who already experienced a PSC, without addition of accessory	15%	10%
Reduction in the incidence of a second PSC with the addition of an accessoryb	50%	50%
Probability first PSC is mild	69% (28/41)	72% (23/32)
Probability first PSC is moderate	29% (12/41)	25% (8/32)
Probability first PSC is severe	2% (1/41)	3% (1/32)
Probability second PSC is mild, given first PSC is mild	0% (0/1)	33%c
Probability second PSC is moderate, given first PSC is mild	100% (1/1)	33%c
Probability second PSC is severe, given first PSC is mild	0% (0/1)	34%c
Probability second PSC is mild, given first PSC is moderate	0% (0/1)	33%c
Probability second PSC is moderate, given first PSC is moderate	100% (1/1)	33%c
Probability second PSC is severe, given first PSC is moderate	0% (0/1)	34%c
Probability second PSC is mild, given first PSC is severe	33%c	33%c
Probability second PSC is moderate, given first PSC is severe	33%c	33%c
Probability second PSC is severe, given first PSC is severe	34%c	34%c

Abbreviations: CIB, ceramide-infused skin barrier; PSC, peristomal skin complication; SoC, standard of care.

^aNumerators and denominators are in parentheses.

^bADVOCATE Study did not provide input on this parameter. Both ceramide-infused skin barrier and SoC values were assumed to be 50% to be conservative.

^cNo values were observed in ADVOCATE; these values are assumptions.