TABLE 4.

Fold Changes and Corresponding P Values of the 15 Candidate miRNAs in the Prediagnostic Cohort

	All Sample Time Points			>10 y Before Diagnosis			5–10 y Before Diagnosis			<5 y Before Diagnosis
miRNA	Cases /Ctrls	FC	P	Cases /Ctrls	FC	P	Cases /Ctrls	FC	P	Cases /Ctrls	FC	P
miR-106b-5p	67/132	0.94	0.132	26/48	0.98	0.854	25/50	0.91	0.154	16/31	0.90	0.057
miR-574-3p	67/132	0.94	0.231	26/48	0.94	0.517	25/50	1.01	0.869	16/31	0.92	0.130
miR-34a-5p	67/132	1.13	0.271	26/47	1.13	0.511	25/49	1.03	0.861	16/31	1.52	0.161
miR-451a	67/132	1.12	0.377	26/48	1.04	0.856	25/50	0.95	0.818	16/31	1.20	0.086
miR-130b-3p	67/132	0.96	0.447	26/47	0.95	0.533	25/50	1.05	0.626	16/31	0.94	0.246
miR-26a-5p	67/132	0.95	0.453	26/48	0.91	0.426	25/50	1.04	0.676	16/31	1.00	0.408
miR-144-3p	67/132	1.08	0.558	26/48	1.02	0.927	25/50	0.95	0.810	16/31	1.14	0.148
miR-423-3p	67/132	1.03	0.660	26/48	1.12	0.276	25/50	1.05	0.621	16/31	1.02	0.250
miR-101-3p	67/132	1.02	0.736	26/48	0.99	0.930	25/50	1.02	0.731	16/31	0.95	0.332
miR-122-5p	67/132	0.96	0.749	26/48	0.92	0.684	25/50	0.80	0.350	16/31	1.00	0.313
miR-24-3p	67/132	0.99	0.877	26/48	1.05	0.478	25/50	1.06	0.402	16/31	0.97	0.046
miR-22-5p	67/132	1.01	0.887	26/48	1.03	0.761	25/50	1.02	0.846	16/31	1.16	0.657
let-7d-3p	67/132	1.01	0.893	26/48	1.03	0.753	25/50	1.14	0.134	16/31	0.94	0.118
miR-197-3p	67/132	1.00	0.949	26/48	1.04	0.613	25/50	1.09	0.292	16/31	0.99	0.159
miR-885-5p	67/132	0.99	0.959	26/48	0.96	0.854	25/50	0.85	0.495	16/31	1.00	0.311

Significant P values in bold. Ctrls indicates controls; FC, fold change; P, Student t test P (not corrected for false discovery rate).