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. 2018 Mar 21;14:1744806918764731. doi: 10.1177/1744806918764731

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Decreased frequency of sEPSC and mEPSC by A317491 incubation. (a) Representative traces illustrating sEPSC of a right IC neuron of control rats before and after an addition of A317491. (b) Cumulative fraction of peak amplitude of sEPSC in an IC pyramidal neuron before (Pre) and after (Post) drug application (left). Bar plots showing no significant change in sEPSC amplitude by A317491 treatment (right). (c) Cumulative fraction of interevent interval of sEPSC in an IC pyramidal neuron before (Pre) and after (Post) drug application (left). Bar plots showing that sEPSC frequency was significantly decreased by A317491 treatment (right, n=9 cells, **p<0.01 vs. Pre, paired sample t test). (d) Representative traces illustrating mEPSC of a right IC neuron of a control rat before and after an addition of A317491. (e) Cumulative fraction of peak amplitude of mEPSC in an IC pyramidal neuron before (Pre) and after (Post) drug application (left). Bar plots showing no significant change in mEPSC amplitude by A317491 treatment (right). (f) Cumulative fraction of interevent interval of mEPSC in an IC pyramidal neuron before (Pre) and after (Post) drug application (left). Bar plots showing that mEPSC frequency was markedly decreased by A317491 treatment (right, n=6 cells, *p<0.05 vs. Pre, paired sample t test). sEPSC: spontaneous excitatory postsynaptic current; mEPSC: miniature excitatory postsynaptic current; NMD: neonatal maternal deprivation.