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. 2018 Mar 21;14:1744806918764731. doi: 10.1177/1744806918764731

Figure 7.

Figure 7.

Effect of IC injection of A317491 or α,β-mATP on CRD threshold. (a) NMD rats showed a lower CRD threshold than CON rats (n=7 for each group, ***p<0.001 vs. CON, Mann–Whiney test). (b) The injection of A317491 (10 nM in 1 μl) into right IC greatly increased CRD threshold of NMD rats (n=5 for each group, *p<0.05 vs. NS, Mann–Whiney test). (c) Injection of α,β-mATP (30 μM in 1 μl) into right IC significantly decreased CRD threshold of CON rats while α,β-mATP at 10 μM did not produce any effect (n=8 for each group, **p<0.01 vs. NS, Kruskal–Wallis test). (d) The CRD threshold was significantly lowered 5 and 15 min after 30 μM α,β-mATP injection into right IC of CON rats (n=8 for each group, **p<0.01 and ***p<0.001 vs. Pre, Kruskal–Wallis test). (e) The injection of α,β-mATP into left IC did not affect the CRD threshold of CON rats (n=7 for each group, Kruskal–Wallis test). CON: control; NMD: neonatal maternal deprivation; NS: normal saline.