Table 2.
Age- and Sex-Specific Frequency and Prevalence of Endocrine Diseases in the Cohort (n = 404)
| Endocrine Disorder | Overall Prevalence (f/n) [95% CI] |
Sex-Specific
|
Age-Specific
a |
||
|---|---|---|---|---|---|
| Prevalence (f/n) [95% CI] | Prevalence (f/n) [95% CI] | ||||
| Diabetes mellitus | 14.7% (52/353) | F | 18.2% (37/203) | Pediatric (<18 y) | 2% (3/152)b |
| [11.2%–18.9%] | [13.2%–24.2%] | [0.4%–5.7%] | |||
| M | 10% (15/150) | Adult | 24.4% (49/201)b | ||
| [5.7%–16%] | [18.6%–30.9%] | ||||
| Atypical growth and sexual maturation | 44.1% (150/340) | F | 40.1% (77/192) | Pediatric (<18 y) | 57.6% (87/151)b |
| [38.8%–49.6%] | [33.1%–47.4%] | [49.3%–65.6%] | |||
| M | 49.3% (73/148) | Adult | 33.3% (63/189)b | ||
| [41%–57.7%] | [26.7%–40.5%] | ||||
| Hypothyroidism | 6.3% (22/352) | F | 8.4% (17/202) | Pediatric (<18 y) | 2.6% (4/152)c |
| [4%–9.3%] | [5%–13.1%] | [0.7%–6.6%] | |||
| M | 3.3% (5/150) | Adult | 9% (18/200)c | ||
| [1.1%–7.6%] | [5.4%–13.9%] | ||||
| Other Reported Endocrine Disorders in the Cohort |
|---|
| Adrenal insufficiency (n = 3) |
| Precocious puberty (n = 5) |
| Dyslipidemia (n = 5) |
| Dysglycemia (n = 5) |
| Growth hormone deficiency (n = 6) |
| Gestational diabetes (n = 1) |
| Hyperthyroidism (n = 2) |
| Hyperparathyroidism (n = 2) |
| Hypoparathyroidism (n = 1) |
| Calcium disturbances (n = 1) |
| Osteopenia/osteoporosis (n = 2) |
| Polycystic ovary syndrome (n = 2) |
| Abnormal menses (n = 2) |
Abbreviations: f, frequency; F, female; M, male; n, total; SE, standard error.
Prevalence is based on age at enrollment in the NAMDC Patient Registry.
P ≤ 0.001, difference between age groups adjusted for sex. Logit (diabetes) = −0.96 (SE: 0.6) + [0.5 (SE: 0.34) if females] − [2.7 (SE: 0.29) if pediatric age]. Odds of (diabetes) = 0.23 + [1.7 (95% CI: 0.85–3.2) if females] + [0.07 (95% CI: 0.02–0.22) if pediatric age]. Logit (AGSM) = −0.5 − (0.25 if females) + (0.97 if pediatric age). Odds of (AGSM) = 0.58 + [0.78 (95% CI: 0.5–1.2) if females] + [2.6 (95% CI: 1.7–4.1) if pediatric age].
P < 0.05, difference between age groups adjusted for sex. Logit (hypothyroidism) = −2.9 + (0.86 if females) − (1.2 if pediatric age). Odds of (hypothyroidism) = 0.05 + [2.4 (95% CI: 0.8–6.6) if females] + [0.3 (95% CI: 0.1–0.9) if pediatric age].