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. 2017 Dec 14;6:401. doi: 10.1038/s41389-017-0003-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Schematic image representing the function of MKP1 on glioma stem cell (GSC) activity and glioblastoma progression. Glioblastoma is a heterogeneous tumor with a population of GSCs (in blue, chemo-, and radiotherapy-resistant) with low levels of MKP1. Genetic MKP1 overexpression or its upregulation with HDACIs increases differentiation, impairs tumor growth, and sensitizes cell to TMZ indicating that elevation of MKP1 might be and interesting approach to extend patient survival and avoid tumor recurrence