Table 2.
Correlations between HHLA2 expression and clinicopathological parameters of patients with CRC
| Characteristic | N | HHLA2
|
||
|---|---|---|---|---|
| Low (%) | High (%) | P-value | ||
| Gender | 0.414 | |||
| Male | 39 | 22 (34.9) | 17 (27.0) | |
| Female | 21 | 11 (17.5) | 13 (20.6) | |
| Age | 0.374 | |||
| ≤64 years | 32 | 15 (23.8) | 17 (27.0) | |
| >64 years | 31 | 18 (28.6) | 13 (20.6) | |
| Depth of invasion (T) | 0.044 | |||
| T2 | 25 | 17 (27.0) | 8 (12.7) | |
| T3, T4 | 38 | 16 (25.4) | 22 (34.9) | |
| Lymph node metastasis ( | N) | 0.845 | ||
| N0 | 37 | 19 (30.2) | 18 (28.6) | |
| N1, N2 | 26 | 14 (22.2) | 12 (19.0) | |
| Distant metastasis (M) | 0.063 | |||
| M0 | 60 | 33 (52.4) | 27 (42.9) | |
| M1 | 3 | 0 (0.0) | 3 (4.8) | |
| AJCC stage | 0.064 | |||
| I, II | 50 | 23 (36.5) | 27 (42.9) | |
| III | 13 | 10 (15.9) | 3 (4.8) | |
| Smoking history | 0.710 | |||
| Yes | 8 | 5 (7.9) | 3 (4.8) | |
| No | 55 | 28 (44.4) | 27 (42.9) | |
| Alcohol history | 1.000 | |||
| Yes | 7 | 4 (6.3) | 3 (4.8) | |
| No | 56 | 29 (46.0) | 27 (42.9) | |
| CD8 status | 0.016 | |||
| Negative | 32 | 12 (19.0) | 20 (31.7) | |
| Positive | 31 | 21 (33.3) | 10 (15.9) | |
| Total | 33 (52.4) | 30 (47.6) | 63 (100) | |
Note: Bold figures represent statistically significant P<0.05.
Abbreviation: CRC, colorectal carcinoma.