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Representation of the interaction between tendon extracellular matrix and cellular signal transduction.
Note: With a predominance of type I in the healthy tendon, collagens interact with growth factors (such as TGFβ) and proteoglycans (such as SLRPs and COMP) that regulate their synthesis and architectural organization. Data from references.22–33
Abbreviation: SLRPs, small leucine-rich proteoglycans.
