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. 2018 Mar 20;11:1571–1581. doi: 10.2147/OTT.S160196

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© 2018 Huang et al. This work is published and licensed by Dove Medical Press Limited

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Knockdown of COL10A1 inhibits cells proliferation in vitro and tumorigenesis in vivo. (A, B) Knockdown of COL10A1 repressed SW480 cells proliferation by CCK-8 assay and colony formation assay. (C) Cells were subcutaneously injected into the right flank of nude mice. Tumor volumes were repeatedly measured on the indicated days to evaluate the effects of COL10A1 on tumor growth. Data points are showed as the mean ± SD tumor volume. **P<0.01, ***P<0.001.

Abbreviations: COL10A1, collagen type X alpha 1 chain; CCK-8, Cell counting kit 8; SD, standard deviation; NC, normal control.