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Five models of the role of ABP in cell regulation: 1) nucleation–promotion of new actin; 2) dynamic regulation of actin filaments by polymerization and depolymerization; 3) barbed-end capping to stop the elongation of actin; 4) cross-linking F-actin into parallel bundles, and 5) anchoring actin filaments to plasma membrane.
Abbreviations: ABP, actin-binding protein; FMN, formin; ECM, extracellular matrix; Arp2/3, actin-related protein 2/3.
