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. Author manuscript; available in PMC: 2018 Mar 23.
Published in final edited form as: Hum Mutat. 2016 Dec 5;38(2):204–215. doi: 10.1002/humu.23147

Figure 2. The DAMAGES molecular signature refines the list of candidate genes in the SFARI autism gene database.

Figure 2

A. All genes represented in the microarray dataset, except those with average log2 intensity <4.5, are projected onto the first two PCs, and shown as a smoothed scatter plot. The gray-scale intensity reflects the local density of genes. A total of 483 genes from the SFARI autism gene database represented in the microarray dataset (asterisks) are overlaid. A subset of these genes were manually scored by experts by considering strength of existing evidence, and these scored genes are distinguished using different colors. A subset of syndromic ASD genes and the five strong candidate genes are highlighted.

B. The percentage of scored genes in each group with a positive or negative DAMAGES score (D-score) is shown. The color codes are the same as in (A). The number of genes in each group is indicated in the parentheses following the gene categories.