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Enrichment of LGD de novo mutations in cases among genes grouped by D-score.
| D-score rank percentile | Number of LGD mutations in cases | Number of LGD mutations in controls | Rate enrichment | P-value |
|---|---|---|---|---|
| Top 25% (n-genes = 3928) | 257 | 45 | 2.76 | 3.2×10−12 |
| Bottom 75% | 318 | 132 | 1.16 | 0.16 |
P-values were calculated by binomial tests to test a null hypothesis that the rate of LGD mutations is the same in cases as in controls in a set of genes.
