Table 2.

Logistic regression for classification of recurrently LGD-mutated genes in ASD and genes LGD-mutated in unaffected siblings.

Features	Estimate	P-value
pLI	2.00	0.0029
Mis_z	0.290	0.019
D-score	2.90	0.0015

We also considered the gene expression rank from brain tissues at mouse embryonic day 9.5 (Brain E9.5; data described in (Homsy, et al., 2015)) as a potential feature. However, in the logistic regression, if we include brain E9.5 together with other features above, the effect size of the feature is not statistically significant from 0 (P-value=0.92). This feature is thus excluded in our final ensemble model.