Paternal cocaine exposure influences basal locomotor activity in males and influences body weight in both male and female offspring. (a) There was a main effect of time as well as paternal exposure on cumulative distance traveled at five-minute time points between saline-sired males (n = 9) and cocaine-sired males (n = 8), but no interaction. (b) A main effect of time was observed with no main effect of paternal exposure or interaction on distance traveled between saline-sired females (n = 9) and cocaine-sired females (n = 9). (c) There was a significant difference between the weights of cocaine-sired males (n = 8) and saline-sired males (n = 9) at P85 and P125. At P85, cocaine-sired males weighed significantly less than saline-sired males. However, at P125, cocaine-sired males weigh significantly more than saline-sired males. (d) There was also a significant difference between the weights of cocaine-sired females (n = 9) compared to saline-sired females (n = 9). At P245, cocaine-sired females weighed significantly more than saline-sired females. *p < 0.05, **p < 0.01. Error bars represent mean ± SEM.