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. Author manuscript; available in PMC: 2018 Aug 14.
Published in final edited form as: Behav Brain Res. 2017 May 26;332:23–31. doi: 10.1016/j.bbr.2017.05.054

Figure 3.

Figure 3

Female cocaine-sired mice exhibit altered cocaine conditioned place preference (CPP). (a) Cocaine CPP with 5mg/kg, i.p. cocaine in saline-sired (n = 8) and cocaine-sired (n = 7) male offspring. (b) Cocaine CPP with 10m/kg, i.p. cocaine in saline-sired (n=14) and cocaine-sired (n=10) male offspring. (c) With 5mg/kg, i.p. cocaine, saline-sired (n = 8) but not cocaine-sired (n = 9) female offspring exhibit a significantly higher CPP score post-conditioning compared to pre-conditioning. During post-conditioning, cocaine-sired females also display significantly lower CPP score compared to saline-sired females. (d) With 10mg/kg, i.p. cocaine, saline-sired (n = 8) and cocaine-sired (n = 9) male offspring both displayed significantly higher CPP scores on post-conditioning compared to pre-conditioning. ***p < 0.001,, post- vs. pre-conditioning. °p < 0.05, saline-sired female versus cocaine-sired female post-conditioning CPP score. Error bars represent mean ± SEM.