Figure 5.

Paternal cocaine exposure increases sucrose consumption in female offspring and anxiety-like behavior in male offspring. (a) There was no significant difference between sucrose consumption of saline-sired and cocaine-sired males in both the pre- and post-testing conditions. (Saline-sired, n = 9; cocaine-sired, n = 8). (b) In the pre- and post-testing conditions, a main effect of paternal exposure was observed with no effect of timing of test and no interaction. Cocaine-sired female mice consumed higher amount of sucrose than saline-sired mice. (Saline-sired, n = 9; cocaine-sired, n = 10). (c–d) There was no significant difference in immobility time in the FST between saline-sired and cocaine-sired males (c, saline-sired, n = 12; cocaine-sired, n = 10) or females (d, saline-sired, n = 10; cocaine-sired, n = 13). (e) Compared to saline-sired males, cocaine-sired males spent significantly less time in the open arms of the elevated-plus-maze (saline-sired, n = 12; cocaine-sired, n = 11). (f) There was no significant difference in the amount of time spent in the open arms between saline-sired females and cocaine-sired females (saline-sired, n = 11; cocaine-sired, n = 13). (g–h) During the social interaction test, both saline-sired and cocaine-sired males (g, saline-sired, n = 15; cocaine-sired, n = 14) and females (h, saline-sired, n = 15; cocaine-sired, n = 15) spent more time with the stranger mouse compared to the novel object. **p < 0.01. Error bars represent mean ± SEM.